close
close

Single-cell approaches to unraveling central nervous system pathologies: insights into pathological mechanisms and therapeutic targets

Posted on by Sweet

The complexity of the central nervous system (CNS) and its pathologies requires a detailed understanding of the cellular and molecular mechanisms at play. Single-cell biology has emerged as a powerful tool for dissecting the heterogeneity and functional dynamics of individual cells of the CNS, offering thus providing unprecedented insights into the cellular landscape of various neurological disorders. This research topic aims to explore the latest advances and applications of single-cell technologies in the study of CNS pathologies, including neurodegenerative diseases, neuroinflammatory conditions and CNS injuries.

This research topic aims to address the critical need for advanced methodologies to study CNS pathologies at the single-cell level. Focusing on single-cell approaches, this research topic aims to bridge the gap between cellular heterogeneity and disease pathology, paving the way for more targeted and effective therapeutic strategies for CNS disorders. By bringing together cutting-edge research, this topic aims to foster collaborations and drive innovation in the field of cellular neuroscience.

This research topic invites original research articles, reviews, and methodological articles that highlight the application of single-cell technologies in CNS research. We seek contributions that provide new insights into the cellular and molecular mechanisms underlying CNS diseases, identify potential therapeutic targets, and discuss the translational potential of single-cell discoveries.

Areas of interest include, but are not limited to:

• Single cell transcriptomics in CNS diseases:

o Gene expression profiling at the cellular level to identify disease-specific cellular states and molecular pathways.

o Understand the heterogeneity and plasticity of neuronal and glial cells in response to CNS pathologies.

• Single-cell epigenomics and epitranscriptomics:

o Investigate epigenetic and epitranscriptomic modifications in individual CNS cells and their implications in disease progression and therapeutic resistance.

• Single-cell proteomics and metabolomics:

o Decipher protein expression patterns and metabolic alterations in individual cells to discover new biomarkers and therapeutic targets.

• Single cell space omics:

o Integrate spatial transcriptomics and proteomics to map cellular interactions and microenvironments in the CNS during health and disease.

• Single-cell technologies in CNS injury and repair:

o Use single-cell approaches to study cellular responses and regenerative processes following CNS injuries such as stroke and head trauma.

• Applications of single-cell CRISPR/Cas9 screening:

o Use single-cell CRISPR/Cas9 technologies to identify key regulators of cell function and survival in CNS pathologies.

• Single-cell multi-omics integration:

o Combine single-cell genomics, transcriptomics, proteomics and metabolomics to achieve a comprehensive understanding of CNS disease mechanisms.

We encourage submissions that provide new insights into the cellular and molecular mechanisms underlying CNS diseases, identify potential therapeutic targets, and discuss the translational potential of single-cell discoveries.

Topic editor Martin Valny is employed by Immunai. All other subject editors declare no competing interests with respect to the research subject.


Keywords: single cell biology, central nervous system, neurodegeneration, neuroinflammation, CNS damage, transcriptomics, epigenomics, proteomics, metabolomics, spatial omics, CRISPR/Cas9, multi-omics integration


Important note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.

The complexity of the central nervous system (CNS) and its pathologies requires a detailed understanding of the cellular and molecular mechanisms at play. Single-cell biology has emerged as a powerful tool for dissecting the heterogeneity and functional dynamics of individual cells of the CNS, offering thus providing unprecedented insights into the cellular landscape of various neurological disorders. This research topic aims to explore the latest advances and applications of single-cell technologies in the study of CNS pathologies, including neurodegenerative diseases, neuroinflammatory conditions and CNS injuries.

This research topic aims to address the critical need for advanced methodologies to study CNS pathologies at the single-cell level. Focusing on single-cell approaches, this research topic aims to bridge the gap between cellular heterogeneity and disease pathology, paving the way for more targeted and effective therapeutic strategies for CNS disorders. By bringing together cutting-edge research, this topic aims to foster collaborations and drive innovation in the field of cellular neuroscience.

This research topic invites original research articles, reviews, and methodological articles that highlight the application of single-cell technologies in CNS research. We seek contributions that provide new insights into the cellular and molecular mechanisms underlying CNS diseases, identify potential therapeutic targets, and discuss the translational potential of single-cell discoveries.

Areas of interest include, but are not limited to:

• Single cell transcriptomics in CNS diseases:

o Gene expression profiling at the cellular level to identify disease-specific cellular states and molecular pathways.

o Understand the heterogeneity and plasticity of neuronal and glial cells in response to CNS pathologies.

• Single-cell epigenomics and epitranscriptomics:

o Investigate epigenetic and epitranscriptomic modifications in individual CNS cells and their implications in disease progression and therapeutic resistance.

• Single-cell proteomics and metabolomics:

o Decipher protein expression patterns and metabolic alterations in individual cells to discover new biomarkers and therapeutic targets.

• Single cell space omics:

o Integrate spatial transcriptomics and proteomics to map cellular interactions and microenvironments in the CNS during health and disease.

• Single-cell technologies in CNS injury and repair:

o Use single-cell approaches to study cellular responses and regenerative processes following CNS injuries such as stroke and head trauma.

• Applications of single-cell CRISPR/Cas9 screening:

o Use single-cell CRISPR/Cas9 technologies to identify key regulators of cell function and survival in CNS pathologies.

• Single-cell multi-omics integration:

o Combine single-cell genomics, transcriptomics, proteomics and metabolomics to achieve a comprehensive understanding of CNS disease mechanisms.

We encourage submissions that provide new insights into the cellular and molecular mechanisms underlying CNS diseases, identify potential therapeutic targets, and discuss the translational potential of single-cell discoveries.

Topic editor Martin Valny is employed by Immunai. All other subject editors declare no competing interests with respect to the research subject.


Keywords: single cell biology, central nervous system, neurodegeneration, neuroinflammation, CNS damage, transcriptomics, epigenomics, proteomics, metabolomics, spatial omics, CRISPR/Cas9, multi-omics integration


Important note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.